notch 1 inhibitor Search Results


notch1 inhibitor dapt gsi-ix gamma-secretase inhibitor ix  (ApexBio)
90
ApexBio notch1 inhibitor dapt gsi-ix gamma-secretase inhibitor ix
HOXA-AS2 promote HPMECs proliferation through regulating <t>Notch1.</t> ( A ) HOXA-AS2 siRNAs were transfected into HPMECs for 24 h, and the relative expression levels of Notch1 were measured by real-time PCR. Notch1 mRNA decreased in HOXA-AS2 knocking down HPMECs. ( B – D ) Western blot was used to analyze the expression of Notch1 protein after transfection with HOXA-AS2 siRNA, overexpressing HOXA-AS2 lentivirus, Notch1 overexpression plasmid or Notch1 inhibitor <t>gamma-Secretase</t> Inhibitor IX (GSI-IX, DAPT 10 mM for 24 h) in HPMECs. ( E – G ) Cell Counting Kit-8 (CCK-8) assay was used to measure HPMECs viability after treatment. All data are presented as mean ± SEM. * P < 0.05. All experiments were performed independently at least 3 times. Abbreviations: HPMECs, human pulmonary microvascular endothelial cells; real-time-PCR, real-time polymerase chain reaction; CCK-8, Cell Counting Kit-8.
Notch1 Inhibitor Dapt Gsi Ix Gamma Secretase Inhibitor Ix, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/notch+1+inhibitor/notch1+inhibitor+dapt+gsi+ix+gamma+secretase+inhibitor+ix/pmc07555270-67-29-36
Average 90 stars, based on 1 article reviews
notch1 inhibitor dapt gsi-ix gamma-secretase inhibitor ix - by Bioz Stars, 2026-10
90/100 stars
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notch-1 inhibitors (compound-e compound-34  (Enzo Biochem)
90
Enzo Biochem notch-1 inhibitors (compound-e compound-34
HOXA-AS2 promote HPMECs proliferation through regulating <t>Notch1.</t> ( A ) HOXA-AS2 siRNAs were transfected into HPMECs for 24 h, and the relative expression levels of Notch1 were measured by real-time PCR. Notch1 mRNA decreased in HOXA-AS2 knocking down HPMECs. ( B – D ) Western blot was used to analyze the expression of Notch1 protein after transfection with HOXA-AS2 siRNA, overexpressing HOXA-AS2 lentivirus, Notch1 overexpression plasmid or Notch1 inhibitor <t>gamma-Secretase</t> Inhibitor IX (GSI-IX, DAPT 10 mM for 24 h) in HPMECs. ( E – G ) Cell Counting Kit-8 (CCK-8) assay was used to measure HPMECs viability after treatment. All data are presented as mean ± SEM. * P < 0.05. All experiments were performed independently at least 3 times. Abbreviations: HPMECs, human pulmonary microvascular endothelial cells; real-time-PCR, real-time polymerase chain reaction; CCK-8, Cell Counting Kit-8.
Notch 1 Inhibitors (Compound E Compound 34, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/notch+1+inhibitor/notch+1+inhibitors++compound+e+compound+34/pm21052088-35-0-5
Average 90 stars, based on 1 article reviews
notch-1 inhibitors (compound-e compound-34 - by Bioz Stars, 2026-10
90/100 stars
  Buy from Supplier

Image Search Results


HOXA-AS2 promote HPMECs proliferation through regulating Notch1. ( A ) HOXA-AS2 siRNAs were transfected into HPMECs for 24 h, and the relative expression levels of Notch1 were measured by real-time PCR. Notch1 mRNA decreased in HOXA-AS2 knocking down HPMECs. ( B – D ) Western blot was used to analyze the expression of Notch1 protein after transfection with HOXA-AS2 siRNA, overexpressing HOXA-AS2 lentivirus, Notch1 overexpression plasmid or Notch1 inhibitor gamma-Secretase Inhibitor IX (GSI-IX, DAPT 10 mM for 24 h) in HPMECs. ( E – G ) Cell Counting Kit-8 (CCK-8) assay was used to measure HPMECs viability after treatment. All data are presented as mean ± SEM. * P < 0.05. All experiments were performed independently at least 3 times. Abbreviations: HPMECs, human pulmonary microvascular endothelial cells; real-time-PCR, real-time polymerase chain reaction; CCK-8, Cell Counting Kit-8.

Journal: International Journal of Chronic Obstructive Pulmonary Disease

Article Title: Microarray Analysis of Long Non-Coding RNAs in Lung Tissues of Patients with COPD and HOXA-AS2 Promotes HPMECs Proliferation via Notch1

doi: 10.2147/COPD.S259601

Figure Lengend Snippet: HOXA-AS2 promote HPMECs proliferation through regulating Notch1. ( A ) HOXA-AS2 siRNAs were transfected into HPMECs for 24 h, and the relative expression levels of Notch1 were measured by real-time PCR. Notch1 mRNA decreased in HOXA-AS2 knocking down HPMECs. ( B – D ) Western blot was used to analyze the expression of Notch1 protein after transfection with HOXA-AS2 siRNA, overexpressing HOXA-AS2 lentivirus, Notch1 overexpression plasmid or Notch1 inhibitor gamma-Secretase Inhibitor IX (GSI-IX, DAPT 10 mM for 24 h) in HPMECs. ( E – G ) Cell Counting Kit-8 (CCK-8) assay was used to measure HPMECs viability after treatment. All data are presented as mean ± SEM. * P < 0.05. All experiments were performed independently at least 3 times. Abbreviations: HPMECs, human pulmonary microvascular endothelial cells; real-time-PCR, real-time polymerase chain reaction; CCK-8, Cell Counting Kit-8.

Article Snippet: The cells were seeded into 96 wells, and treated with the HOXA-AS2 siRNA, or CSE at different concentrations of 0, 0.5%, 1%, 2.5%, and 5%, or 10 mM of Notch1 inhibitor DAPT (GSI-IX, gamma-Secretase Inhibitor IX, ApexBio Technology, TX, USA) for 24h.

Techniques: Transfection, Expressing, Real-time Polymerase Chain Reaction, Western Blot, Over Expression, Plasmid Preparation, Cell Counting, CCK-8 Assay